Chloroquine Neuromyopathy

Internalised capillaries, neuromyopathy and myalgia.

Internalised capillaries are described in the muscle fibres of two adult males who complained of exertional myalgia. In one patient, "bundles" of internalised capillaries were found in 2% of the Type 1 fibres and many of the Type 1 fibres exhibited non-specific cytoarchitectural changes. The other had hereditary motor and sensory neuropathy (HMSN) Type 2 and his muscle biopsy exhibited the more...

Colchicine neuromyopathy: a report of six cases.

Colchicine has been in use for therapeutic purposes for many years. It can, however, cause subacute onset muscle and peripheral nerve toxicity in patients with chronic renal failure. In this report we describe 6 patients who developed neuromyopathy after the administration of colchicine. All patients presented with proximal muscle weakness, elevated serum creatine kinase (CK) levels, and neurop...

Prophylactic Effect of Chloroquine and Hydroxy chloroquine in COVID-19 Treatment

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety.Hydroxychloroquine (HCQ) is an anti-malaria drug; its antiviral properties are controversial,and some in vitr...

Chloroquine diphosphate

Human toxicity Chloroquine is a potentially fatal poisoning, often characterized by rapid deterioration. Features of toxicity may develop within 1 to 2 h, and death may occur abruptly, generally from myocardial depression and dysrhythmia. Symptoms at an acute overdose are as following: hyperexcitability, agitation, seizures, cerebral edema, ventricular dysrhythmia, hypotension, shock, cardiac a...

Chloroquine myopathy.